Vitsa is one of the largest villages of central Zagori. It is situated at an altitude of 955m on a mountain slope near the Vikos gorge with roads linking it to Greek National Road 6. Vitsa is famous for its old double-arched bridge of Missios.
During ancient times, Zagori was inhabited by the Molossians. Excavations in the location Genitsari near Vitsa led to the discovery of a settlement possibly of the Tymphaeans or theMolossians dated to the 9th until the 4th century BC. There were signs of the foundations of small buildings from the archaic (geometric) and classical periods and a graveyard with at least 140 graves that contained coins, pottery and weaponry.
The establishment of the village of Vitsa is referred to in other documents from 1321 to 1361, under the name of Vezitsa. Some buildings from Byzantine times are still preserved. The village is divided by a chasm in two districts that were once different villages called Ano Vitsa and Kato Vitsa (Upper and Lower Vitsa).These two villages were always considered, along with Monodendri, as more or less one village, due to their small distance.